The Cytoprotective Effects of Tumor Necrosis Factor Are Conveyed Through Tumor Necrosis Factor Receptor–Associated Factor 2 in the Heart
نویسندگان
چکیده
منابع مشابه
The cytoprotective effects of tumor necrosis factor are conveyed through tumor necrosis factor receptor-associated factor 2 in the heart.
BACKGROUND Activation of both type 1 and type 2 tumor necrosis factor (TNF) receptors (TNFR1 and TNFR2) confers cytoprotection in cardiac myocytes. Noting that the scaffolding protein TNF receptor-associated factor 2 (TRAF2) is common to both TNF receptors, we hypothesized that the cytoprotective responses of TNF were mediated through TRAF2. METHODS AND RESULTS Mice with cardiac-restricted ov...
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ژورنال
عنوان ژورنال: Circulation: Heart Failure
سال: 2010
ISSN: 1941-3289,1941-3297
DOI: 10.1161/circheartfailure.109.899732